A case of adult-onset autoimmune enteropathy

VernacularTitle:成人自身免疫性肠病一例
Author: Qiao ZHONG ¹ ; Liang FANG ; Yanyan CHEN ; Guobin XU ; Meifang HUANG ; Qiu ZHAO ; Shuyuan XIAO ; Min CHEN
Author Information

1. 武汉大学中南医院消化内科，武汉　430071
Publication Type:Journal Article
Keywords: Autoimmune enteropathy, adult; Chronic diarrhea; Villous atrophy
From: Chinese Journal of Inflammatory Bowel Diseases 2023;07(1):90-92
CountryChina
Language:Chinese
Abstract: This paper reports a case of adult-onset autoimmune enteropathy (AIE) diagnosed and treated at the Department of Gastroenterology in Zhongnan Hospital of Wuhan University. The patient had intermittent abdominal pain with diarrhea and weight loss as the main clinical manifestations. Laboratory examination results showed increased IgG and IgE, and positive antinuclear antibody (ANA) . Obvious villous atrophy of duodenum and ileum was observed under endoscopy. The intestinal biopsy showed villous atrophy of duodenum, reduction of goblet cells, lymphocyte infiltration of the lamina propria and flattening and blunting of villous of ileum mucosa. The patient was comprehensively diagnosed as AIE. Prednisone therapy is effective and the patients is being followed up closely. Adult-onset AIE is rare. Summarizing the diagnosis and treatment experience of this patient is helpful to improve clinicians′ understanding of diagnosis and differential diagnosis of AIE.