Association between growth hormone peak and body fat percentage in children with short stature
10.3760/cma.j.cn311282-20250225-00096
- VernacularTitle:身材矮小儿童生长激素峰值和体脂百分比的相关性研究
- Author:
Qianqian ZHAO
1
;
Mei ZHANG
;
Yanying LI
;
Yanhong ZHANG
;
Xinguo HOU
;
Hui PAN
;
Bo BAN
Author Information
1. 济宁医学院附属医院内分泌遗传代谢科，济宁 272000
- Publication Type:Journal Article
- Keywords:
Short stature;
Growth hormone peak;
Body fat;
Body fat percentage;
Growth hormone deficiency
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(6):476-481
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between peak growth hormone(GH) levels and body fat mass as well as body fat percentage in children with short stature.Methods:This retrospective study included 477 children diagnosed with short stature at the Affiliated Hospital of Jining Medical University between January 2021 and November 2024, based on data from the Growth and Development Disease Follow-up Cohort Study(GDDSD) in Shandong Province. Clinical data including anthropometric measurements, laboratory tests, and body composition were collected. The relationship between GH peak and body fat mass and percentage were analyzed using smooth curve fitting and multiple piecewise linear regression models.Results:In univariate linear regression analysis, both body fat mass and body fat percentage were positively correlated with age, height, weight, body mass index, triglycerides, low density lipoprotein-cholesterol, fasting blood glucose, total body water, protein, and skeletal muscle mass(all P<0.05), and negatively correlated with GH peak and high density lipoprotein-cholesterol. After adjusting for potential confounding factors, a nonlinear relationship was observed between GH peak and both body fat mass and body fat percentage, with inflection points at 6.80 ng/mL and 7.75 ng/mL, respectively. When GH peak was below the inflection point, it was significantly negatively correlated with body fat mass and percentage( P<0.001). However, when GH peak exceeded the inflection point, the associations were no longer statistically significant( P>0.05). Conclusions:This study demonstrates a nonlinear relationship between peak GH levels and body fat percentage in children with short stature. At lower GH peaks, both body fat mass and body fat percentage increase significantly, which may contribute to an elevated future risk of cardiovascular disease.
