The fluctuations of thyroid function in a childbearing-age-woman with Graves′ disease: One case report
10.3760/cma.j.cn311282-20241009-00451
- VernacularTitle:一例患Graves病的育龄女性甲状腺功能波动的病例报道
- Author:
Peiheng ZHANG
1
;
Yu WANG
;
Weijie SUN
;
Yang ZHANG
;
Huixia YANG
;
Ying GAO
Author Information
1. 北京大学第一医院内分泌科，北京 100034
- Publication Type:Journal Article
- Keywords:
Graves′ disease;
Thyroid-stimulating hormone receptor stimulating antibodies;
Thyroid-stimulating hormone receptor blocking antibodies;
Pregnancy
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(3):237-241
- CountryChina
- Language:Chinese
-
Abstract:
In patients with Graves′ disease, repeated transition between hyperthyroidism and hypothyroidism is uncommon. This report describes a female Graves′ disease patient with persistently high levels of thyroid-stimulating hormone receptor antibodies, who experienced multiple transitions between hyperthyroidism and hypothyroidism over a 7-year follow-up period, including during pregnancy. The fluctuations may be linked to the interplay between thyroid-stimulating hormone receptor stimulating antibody(TSAb) and thyroid-stimulating hormone receptor blocking antibody(TBAb). Treatment with either antithyroid medications or levothyroxine sodium, based on the patient′s thyroid status, helped maintain normal thyroid function. Stable thyroid function may contribute to maintaining a consistent thyroid immune status and reducing thyroid function fluctuation.
