The role of abnormal composition of innate lymphoid cells in the occurrence and development of inflammatory bowel disease
10.3760/cma.j.cn101480-20210529-00039
- VernacularTitle:固有淋巴细胞组成异常在炎症性肠病发生发展中的作用
- Author:
Mingyang XU
1
;
Fangmei LING
1
;
Junrong LI
1
;
Yidong CHEN
1
;
Liangru ZHU
1
Author Information
1. 华中科技大学同济医学院附属协和医院消化内科，武汉 430022
- Publication Type:Journal Article
- Keywords:
Innate lymphoid cells;
Cell composition;
Inflammatory bowel disease;
Intestinal homeostasis
- From:
Chinese Journal of Inflammatory Bowel Diseases
2022;06(3):267-270
- CountryChina
- Language:Chinese
-
Abstract:
Innate lymphoid cells (ILC) are a type of innate immune cells with adaptive immune function, which can secrete a variety of cytokines and regulate immune response. In recent years, more and more studies have confirmed that there are abundant ILC in the lamina propria of the human intestinal mucosa, and are closely related to the occurrence and development of inflammatory bowel disease (IBD) . When intestinal inflammation occurs, the composition of ILC also appears abnormal. This article reviews the role of abnormal composition of ILC in the occurrence and development of IBD from the aspects of composition and function of ILC, the influence of its abnormal composition on IBD and possible mechanisms.
