Study about the role of long noncoding RNA CCDC18-AS1 in primary hyerparathyroidism
10.3760/cma.j.cn311282-20240822-00370
- VernacularTitle:长链非编码RNA CCDC18-AS1在原发性甲状旁腺功能亢进症中的作用研究
- Author:
Dongxue ZHANG
1
;
Teng ZHAO
;
Jian HUANG
;
Bojun WEI
;
Tao JIANG
Author Information
1. 首都医科大学附属北京世纪坛医院内分泌科，北京 100038
- Publication Type:Journal Article
- Keywords:
Parathyroid carcinoma;
Long noncoding RNA CCDC18-AS1;
Hypophosphatemia
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(3):219-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of long noncoding RNA(lncRNA) CCDC18-AS1 in parathyroid carcinoma(PC) diagnosis.Methods:This cross-sectional study included 55 patients with primary hyperparathyroidism treated at Beijing Shijitan Hospital from 2013 to 2024. Of these, 12 patients were diagnosed with PC and 43 with parathyroid adenoma(PA). Tissue samples and clinical data were collected, and lncRNA CCDC18-AS1 expression were measured using real-time quantitative PCR(RT-qPCR).Results:LncRNA CCDC18-AS1 expression was significantly higher in the PC group than that in the PA group( P=0.003). It was identified as an independent risk factor for PC, independent of age, sex, or serum calcium levels. Among patients with hypophosphatemia, no significant differences in lncRNA CCDC18-AS1 expression was observed between the PC and PA groups. However, in patients with normal serum phosphate levels, lncRNA CCDC18-AS1 expression was significantly higher in the PC group( P<0.001) and showed a positive correlation with serum phosphorus concentration( P=0.001). The area under the receiver operating characteristic(ROC) curve(AUC) for lncRNA CCDC18-AS1 in PC diagnosis was 0.758(95% CI 0.620-0.866, P=0.005), comparable to that of lncRNA plasmacytoma variant translocation 1(PVT1). Among patients with normal serum phosphate, the AUC for lncRNA CCDC18-AS1 increased to 0.969(95% CI 0.835-0.999, P<0.001), with 100% sensitivity and 92.31% specificity, suggesting superior diagnostic performance compared to PVT1(0.840, 95% CI 0.653-0.950, P=0.001). Conclusions:LncRNA CCDC18-AS1 may serves as a potential biomarker for PC diagnosis, with greater diagnostic value in patients with normal serum phosphorus levels.
