Association between insulin resistance surrogate indicators and early-stage kidney injury in type 2 diabetes
10.3760/cma.j.cn311282-20240322-00114
- VernacularTitle:胰岛素抵抗替代指标与糖尿病早期肾损伤关系的研究
- Author:
Xinyan ZHANG
1
;
Lina CHEN
;
Yanbo LI
;
Hui RAN
;
Qing SU
;
Hongmei ZHANG
Author Information
1. 上海交通大学医学院附属新华医院内分泌科 200092
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Early-stage kidney injury;
Insulin resistance;
Surrogate indicators
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(1):40-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between insulin resistance surrogate indicators and early-stage kidney injury in type 2 diabetes mellitus(T2DM).Methods:A total of 918 T2DM patients hospitalized in the Endocrinology Department of Xinhua Hospital from January 2018 to December 2020 were selected, including 313 patients with early-stage kidney injury and 605 without. Differences in insulin resistance surrogate indicators, including triglyceride to high-density lipoprotein cholesterol ratio(TG/HDL-C), triglyceride glucose(TyG) index, and triglyceride glucose-body mass index(TyG-BMI), were compared between the two groups. Factors associated with early-stage kidney injury in T2DM were analyzed, and the impact of TG/HDL-C, TyG index, and TyG-BMI on early-stage kidney injury in T2DM were explored.Results:Compared with T2DM patients without early-stage kidney injury, those with early-stage kidney injury exhibited significantly elevated levels of TG/HDL-C, TyG index, and TyG-BMI( P< 0.001). TG/HDL-C, TyG index, TyG-BMI, age, duration of diabetes, systolic blood pressure, fasting insulin, and HbA 1C were identified as independent risk factors for early-stage kidney injury in T2DM. Compared to the Q1 quartile, the risk in the Q4 quartile was 3.168 times(95% CI 1.993-5.036) for TG/HDL-C, 2.714 times(95% CI 1.710-4.306) for TyG index, and 2.893 times(95% CI 1.820-5.598) for TyG-BMI. Conclusion:Insulin resistance surrogate indicators TG/HDL-C, TyG index, and TyG-BMI are significantly elevated in T2DM patients with early-stage kidney injury, serving as independent risk factors for early-stage renal impairment in T2DM.
