Association of skeletal muscle fat index with insulin resistance and type 2 diabetes mellitus
10.3760/cma.j.cn311282-20240530-00231
- VernacularTitle:骨骼肌脂肪指数与胰岛素抵抗及2型糖尿病的相关性研究
- Author:
Hongxia LIU
1
;
Mingyu ZHU
1
;
Tingting HAN
1
;
Ningxin CHEN
1
;
Yue LIU
1
;
Ziyi WEI
1
;
Yurong WENG
1
;
Yaomin HU
1
Author Information
1. 上海交通大学医学院附属仁济医院老年科，上海 200127
- Publication Type:Journal Article
- Keywords:
Skeletal muscle fat index;
Insulin resistance;
Diabetes mellitus, type 2;
Skeletal muscle index
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(12):1032-1037
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of skeletal muscle fat index(SMFI) with insulin resistance and type 2 diabetes mellitus.Methods:This retrospective study included 1 100 patients from Department of Geriatric, Renji Hospital, Shanghai Jiao Tong University School of Medicine from October 2020 to October 2023. The SMFI measured by chest computed tomography(CT) is used as an indicator to evaluate the quality of skeletal muscle. Spearman and linear regression analysis were used to evaluate the association between SMFI and homoeostasis model assessment for insulin resistance(HOMA-IR). Multivariate logistic regression analysis and restricted cubic spline(RCS) were used to analyze the association of HOMA-IR with the prevalence of type 2 diabetes mellitus. Finally, interaction and stratified analyses were conducted according to age, sex, body mass index, estimated glomerular filtration rate, uric acid, skeletal muscle index(SMI), smoking, alcohol drinking, hypertension, and dyslipidemia.Results:SMFI showed a significant positive correlation with HOMA-IR( r=0.385, P<0.001). Each 1-unit increase in SMFI led to 0.009, 0.011, 0.004, 0.004, and 0.004 rise in HOMA-IR across adjusted models(all P<0.05). Then subjects were stratified into tertiles( T1, T2, and T3) according to SMFI. Logistic regression analysis revealed that the prevalence of type 2 diabetes mellitus significantly increased in T2( OR=2.37, 95% CI 1.30-4.31, P=0.005) and T3( OR=2.85, 95% CI 1.39-5.86, P=0.004) compared to T1. RCS analysis showed that the prevalence of type 2 diabetes mellitus increased with the increase of SMFI when SMFI<157.195. The results of subgroup analysis showed that female, under 60 years old, body mass index<24 kg/m 2, uric acid<420 μmol/L, low SMI, non-smoking, non-alcoholic drinking, and non-hypertensive individuals with higher SMFI were more likely to develop type 2 diabetes mellitus. Conclusions:Elevated SMFI is positively associated with insulin resistance and type 2 diabetes mellitus risk. Reducing SMFI below 157.195 may significantly lower the risk of type 2 diabetes mellitus.
