Research progress of m 6A RNA methylation modification in inflammatory bowel disease
10.3760/cma.j.cn101480-20210325-00024
- VernacularTitle:m 6A RNA甲基化修饰在炎症性肠病中的研究进展
- Author:
Lichao YANG
1
;
Guotao WU
1
;
Qiang WU
1
;
Lianwen YUAN
1
Author Information
1. 中南大学湘雅二医院老年外科，长沙 410011
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
m 6A;
Inflammation;
Immunity;
Intestinal microflora
- From:
Chinese Journal of Inflammatory Bowel Diseases
2022;06(2):174-178
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine. In recent years, it has been found that m 6A methylation, as the most abundant mRNA modification in mammalian cells, is closely related to the occurrence and development of IBD. The key enzymes of m 6A (METTL3, METTL4, FTO, etc.) can not only regulate the changes of inflammation and immunity in IBD, but also have bidirectional feedback regulation with intestinal microenvironment. Therefore, this paper focuses on the research progress of m 6A RNA methylation modification in IBD in recent years, in order to deeply understand the pathogenesis of IBD from the epigenetic level, and provide a new direction for exploring targeted m 6A modification-related proteins to treat IBD in the future.
