Analysis of levels of serum trace elements in Crohn′s disease
10.3760/cma.j.cn101480-20210925-00071
- VernacularTitle:克罗恩病患者血清微量元素含量分析
- Author:
Jun DENG
1
;
Miao LI
;
Min ZHI
;
Xiang GAO
;
Qin GUO
Author Information
1. 中山大学附属第六医院消化内科，广州 510655
- Publication Type:Journal Article
- Keywords:
Crohn′s disease;
Trace elements;
Serum;
Differences
- From:
Chinese Journal of Inflammatory Bowel Diseases
2022;06(1):55-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the change of levels of serum trace elements in patients with Crohn′s disease (CD) .Methods:A retrospective case-control study was conducted. The clinical data of 240 patients with CD (CD group) treated in the Department of Gastroenterology of the Sixth Affiliated Hospital of Sun Yat-sen University from August 2020 to August 2021 were collected and analyzed. At the same time, 50 healthy people were selected as the normal control group. The levels of trace elements such as serum lead, manganese, copper, zinc, iron and magnesium of all subjects were collected. The differences in levels of serum trace elements between CD patients in remission period and active period, and CD group and normal control group were compared respectively.Results:Among the 240 patients with CD, 166 were males and 74 were females. The age was (30.46 ± 10.43) (9 - 69) years old, and the body mass index was (19.51 ± 2.88) kg/m 2. The ratio of trace element abnormalities in CD female patients was higher than male (56.76% vs. 40.96%, P = 0.023). Compared with CD patients in remission period, the serum copper level of CD patients in active period [ (1000.60 ± 185.19) μg/L vs. (820.79 ± 128.32) μg/L, P<0.05] and ratio of copper to zinc (172.63 ± 44.83 vs. 136.34 ± 26.87, P<0.05) were higher, while serum iron was lower [ (409.75 ± 73.28) mg/L vs. (471.18 ± 56.71) mg/L, P<0.05]. Compared with the normal control group, the ratio of trace element abnormalities was higher in CD group (45.83% vs. 30.00%, P = 0.04), the serum iron level was lower [ (434.32 ± 73.49) mg/L vs. (469.69 ± 52.02) mg/L, P<0.05], and the serum copper level was higher [ (928.68 ± 186.70) μg/L vs. (796.26 ± 104.75) μg/L, P<0.05], the ratio of copper to zinc was higher (158.12 ± 42.51 vs. 131.45 ± 22.90, P<0.05) . Conclusions:The serum trace element abnormalities occurr in part of CD patients, and are more common in female patients. The serum copper level and the ratio of copper to zinc in CD patients are higher, while the serum iron level is lower, which may be related with the inflammatory activity of the disease.
