Effect of endoscopic characteristics on endoscopic remission after treatment in active patients with ulcerative colitis
10.3760/cma.j.cn101480-20210224-00014
- VernacularTitle:活动期溃疡性结肠炎患者内镜特征对治疗后内镜缓解的影响
- Author:
Xiafei CHEN
1
;
Chenghu XU
1
;
Xiaoqi ZHANG
1
;
Xiaoping ZOU
1
Author Information
1. 南京大学医学院附属鼓楼医院消化内科，南京 210008
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Endoscopy;
Endoscopic characteristics;
Endoscopic remission;
Cox regression analysis
- From:
Chinese Journal of Inflammatory Bowel Diseases
2022;06(1):50-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the endoscopic characteristics in patients with active ulcerative colitis (UC) affect the endoscopic remission after treatment.Methods:A retrospective case-control study was conductd. The clinical and endoscopic data of 79 cases who underwent colonoscopy in Nanjing Drum Tower Hospital from January 2014 to September 2020 were collected. Mayo endoscopic score (MES) ≤1 was defined as endoscopic remission. Patients were divided into remission and non-remission groups based on the endoscopic remission after treatment achieved or not. Univariate and multivariate analyses were performed to screen the factors affecting endoscopic remission in UC patients by Cox regression.Results:Among the 79 UC patients, 33 were male and 46 were female, with a median age of 42.0 (27.0) years and a median disease course of 30.0 (63.0) months. There were 33 cases in remission group and 46 cases in non-remission group. The composition proportion of the two groups was significantly different in the choice of therapeutic drugs in the treatment of patients ( P<0.05), and there were no statistically significant differences in other clinical data (all P>0.05). Univariate analysis suggested that the complete disappearance of vascular texture (39.4% vs. 76.1%, HR=0.303, 95% CI: 0.146-0.626, P=0.001) and inflammatory hyperplastic polyps (27.3% vs. 67.4%, HR=0.264, 95% CI: 0.118-0.588, P=0.001) were less in the remission group than those in the non-remission group.Multivariate analysis after correction for confounding factors indicated that complete disappearance of vascular texture ( HR=0.455, 95% CI: 0.208- 0.995, P=0.048) and inflammatory hyperplastic polyps ( HR=0.364, 95% CI: 0.153-0.868, P=0.023) were still independent risk factors affecting endoscopic remission. Active UC patients with inflammatory polyps and complete disappearance of vascular texture are difficult to achieve endoscopic remission, with the risk increasing by 63.6% and 54.5% respectively. Conclusions:Inflammatory hyperplastic polyps and complete loss of vascular texture are independent risk factors for endoscopic remission in patients with active UC.
