Serum ferritin and triglyceride-glucose index interaction on metabolic dysfunction-associated fatty liver disease
10.3760/cma.j.cn311282-20240827-00378
- VernacularTitle:血清铁蛋白与三酰甘油葡萄糖指数的交互作用对代谢相关脂肪性肝病的影响
- Author:
Lei GAO
1
;
Weihong ZHOU
;
Wenxia CUI
;
Fenghui PAN
;
Dinghuang MU
;
Yun HU
Author Information
1. 南京医科大学鼓楼临床医学院老年医学科，南京 210008
- Publication Type:Journal Article
- Keywords:
Serum ferritin;
Triglyceride-glucose index;
Metabolic dysfunction-associated fatty liver disease;
Interaction effect
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(2):106-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between serum ferritin(SF), triglyceride-glucose(TyG) index, and metabolic dysfunction-associated fatty liver disease(MAFLD), and to assess their interaction on MAFLD risk in the health checkup population.Methods:A cross-sectional analysis was conducted with 1 439 participants from the Health Management Centre of Nanjing Drum Tower Hospital in 2022. Data were collected through physical examination, laboratory tests, and abdominal imaging. Differences in metabolic indicators, SF, and TyG index were compared between MAFLD and non-MAFLD groups. Logistic regression analysis was used to assess the associations of SF and TyG index with MAFLD, and their on MAFLD interaction was evaluated. Results:Both SF and TyG index were significantly higher in the MAFLD group between than those in the non-MAFLD group( P<0.05). After adjusting for sex, age, history of hypertension, history of diabetes, body mass index, waist circumference, haemoglobin, alanine aminotransferase, aspartate aminotransferase, and uric acid, the SF and TyG index were positively associated with the risk of MAFLD[ OR(95% CI), SF: 1.00(1.00-1.00); TyG index: 2.98(2.19-4.06). The additive interaction analysis showed that the risk of MAFLD was significantly higher in the G4 group(SF≥135.4 ng/mL, TyG index≥8.52) compared to the G1 group(SF<135.4 ng/mL, TyG index<8.52) [ OR 4.43(95% CI 2.70-7.25)]. Conclusions:Elevated SF and TyG index were independently associated with increased risk of MAFLD, with a significant synergistic interaction between the two.
