Management of 99Tc m-MIBI-negative primary hyperparathyroidism complicated with papillary thyroid carcinoma

VernacularTitle:99Tc m-MIBI显像阴性的原发性甲状旁腺功能亢进症合并甲状腺乳头状癌的治疗选择
Author: Jingwen YU ¹ ; Xi ZHANG ; Haiwei LIU
Author Information

1. 海南省人民医院内分泌科，海口　570311
Publication Type:Journal Article
Keywords: Primary hyperparathyroidism; 99Tc m-MIBI negativity; Papillary thyroid carcinoma
From: Chinese Journal of Endocrinology and Metabolism 2025;41(1):61-64
CountryChina
Language:Chinese
Abstract: Primary hyperparathyroidism(PHPT) is a relatively common endocrine disorder in clinical practice. While the diagnosis and characterization of this condition are straightforward, cases with negative 99Tc m-methoxyisobutylisonitrile( 99Tc m-MIBI) imaging often complicates lesion localization, posing a clinical challenge in determining whether surgical intervention is warranted. This paper presents two cases of PHPT with negative 99Tc m-MIBI imaging, both diagnosed with papillary thyroid carcinoma(PTC). Following bilateral neck exploration, the surgeons successfully localized and excised the hyperparathyroid lesions and provided appropriate treatment for PTC. Postoperative follow-up indicated favorable recovery in both patients. This article aims to dive deeply into the necessity of surgical intervention and enhance clinical management of these cases.