Multiple endocrine adenomatosis(MEN) type 4: A new member of the MEN family
10.3760/cma.j.cn311282-20240724-00327
- VernacularTitle:多发性内分泌腺瘤病(MEN)4型：MEN家族的新成员
- Author:
Yuke LIU
1
;
Junsong ZENG
;
Huiwen TAN
;
Jianwei LI
;
Yerong YU
Author Information
1. 四川大学华西医院内分泌代谢科，成都 610041
- Publication Type:Journal Article
- Keywords:
Multiple endocrine adenomatosis, type 4;
Primary hyperparathyroidism;
CDKN1B gene
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(12):1083-1086
- CountryChina
- Language:Chinese
-
Abstract:
Multiple endocrine neoplasia(MEN) is a rare autosomal dominant genetic disorder characterized by hyperplasia or tumor development in two or more endocrine glands. Currently, MEN is classified into four subtypes: MEN1, MEN2, MEN3, and MEN4. Among these, MEN4 is caused by mutations in the CDKN1B gene and presents clinical manifestations similar to MEN1, though the age of onset and disease progression differ. Due to its rarity, this article reviews the pathogenesis and treatment strategies for MEN4, aiming to provide valuable insights for its diagnosis and management.
