Batokines in the cross-talk between brown adipose tissue and other organs: An update

VernacularTitle:棕色脂肪因子在棕色脂肪组织与其他器官相互交流中的作用及机制的研究进展
Author: Hao LIU ¹ ; Jie CHEN ; Danqi QIU ; Kailai XU ; Li LI ; Shuqin CHEN
Author Information

1. 宁波大学附属第一医院内分泌科，宁波　315000
Publication Type:Journal Article
Keywords: Brown fat tissue; Batokines; Metabolism; Organ communication
From: Chinese Journal of Endocrinology and Metabolism 2025;41(2):156-163
CountryChina
Language:Chinese
Abstract: Brown adipose tissue(BAT), a metabolically active organ, not only plays a pivotal role in thermogenesis, but also exerts endocrine effects that regulate both its own metabolic processes and the function of various other organ systems. These effects are primarily mediated by brown adipose tissue-derived factors, or batokines. Recent advances in the understanding of batokine types, target organs, and underlying mechanisms have highlighted their significant role in the crosstalk between BAT and other organs. This review focuses on the various batokines secreted by BAT and their involvement in regulating interactions with key target organs such as the liver, cardiovascular system, skeletal muscle, and nervous system. By examining the specific functions and molecular mechanisms of these factors, this review aims to offer novel insights and suggest potential research directions for the prevention and treatment of related metabolic diseases.