Efficacy and safety of insulin glargine 300 U/mL in patients with type 2 diabetes mellitus in China: Interpretation of INITIATION study and its implications

VernacularTitle:甘精胰岛素300 U/mL在中国2型糖尿病患者中的疗效和安全性：INITIATION研究解读及带来的启示
Author: Linong JI ¹ ; Liming CHEN
Author Information

1. 北京大学人民医院内分泌科，北京　100044
Publication Type:Journal Article
Keywords: Diabetes mellitus, type 2; Basal insulin; Insulin glargine 300 U/mL
From: Chinese Journal of Endocrinology and Metabolism 2025;41(2):89-92
CountryChina
Language:Chinese
Abstract: Basal insulin plays a crucial role in the treatment of patients with type 2 diabetes mellitus(T2DM). Previous clinical trials have demonstrated that insulin glargine 300 U/mL(Gla-300) is effective in improving glycaemic control with a relatively low risk of hypoglycaemia. However, there is limited real-world data on its effectiveness and safety in China. This article reviews the INITIATION study, which evaluated the use of Gla-300 in clinical practice in China, demonstrating that Gla-300 is an effective treatment option for Chinese adults with suboptimally controlled T2DM, whether insulin-na?ve or switching from other basal insulins.