Association of cardiovascular health metrics with microvascular complications in patients with type 2 diabetes mellitus
10.3760/cma.j.cn311282-20240905-00398
- VernacularTitle:2型糖尿病患者心血管健康指标和微血管并发症的关系
- Author:
Xiaoting CHEN
1
;
Miao XU
1
;
Li LI
1
;
Jialin LI
1
Author Information
1. 宁波大学附属第一医院内分泌代谢科 315010
- Publication Type:Journal Article
- Keywords:
Microvascular complications;
Cardiovascular health metrics;
Diabetes mellitus, type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(1):33-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between cardiovascular health(CVH) metrics and microvascular complications in patients with type 2 diabetes mellitus(T2DM).Methods:A cross-sectional study was conducted with 4 614 T2DM patients who received standardized metabolic disease management at the First Affiliated Hospital of Ningbo University from March 1st, 2018, to February 29th, 2024. Ideal CVH metrics were defined as non-smoking, non-drinking or moderate drinking, a healthy diet, regular physical activity, a healthy waist circumference, and adequate sleep duration. Microvascular complications included diabetic kidney disease(DKD), diabetic retinopathy(DR), and diabetic peripheral neuropathy(DPN). Logistic regression analysis was used to assess the relationship between CVH metrics and microvascular complications. Results:Patients with≤1, 2, 3, 4, or≥5 ideal CVH metrics were 378(8.2%), 933(20.2%), 1 480(32.1%), 1 218(26.4%), and 605(13.1%), respectively. A total of 2 736(59.3%) patients had at least one microvascular complication. Multivariate logistic regression analysis showed that compared to those with≤1 ideal CVH metric, patients with≥5 ideal CVH metric had an odds ratio( OR) of 0.55(95% CI 0.41-0.74, Ptrend<0.001) for microvascular complications, an OR of 0.51(95% CI 0.36-0.72, Ptrend<0.001) for DKD, and an OR of 0.54(95% CI 0.40-0.73, Ptrend<0.001) for DPN. No significant association was found for DR, with an OR of 1.31(95% CI 0.87-1.98, Ptrend=0.615). Conclusion:A great number of ideal CVH metrics was associated with a reduction in microvascular complications in T2DM patients, with variations across different types of microvascular complications.
