Megamonas promotes lipid absorption and obesity
10.3760/cma.j.cn311282-20241106-00525
- VernacularTitle:肠道巨单胞菌促进脂质吸收与肥胖
- Author:
Chao WU
1
;
Mingxi ZONG
1
;
Ruixin LIU
1
Author Information
1. 上海交通大学医学院附属瑞金医院内分泌代谢病科，上海市内分泌代谢病研究所，国家代谢性疾病临床医学研究中心(上海)，上海 200025
- Publication Type:Journal Article
- Keywords:
Obesity;
Polygenic risk score;
Gut microbiota;
Megamonas;
Myo-inositol;
Lipid absorption
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(12):1004-1006
- CountryChina
- Language:Chinese
-
Abstract:
Obesity is a significant public health concern, with numerous studies emphasizing the critical role of gut microbiota in its development. However, the specific microbes contributing to obesity and the underlying pathogenic mechanisms remain unclear. This article mainly introduces our recent publication in Cell Host Microbe titled " Obesity-enriched gut microbe degrades myo-inositol and promotes lipid absorption" [Wu C, Yang F, Zhong H, et al. Obesity-enriched gut microbe degrades myo-inositol and promotes lipid absorption. Cell Host Microbe, 2024, 32(8): 1301-1314.e9. DOI: 10.1016/j.chom.2024.06.012.]. The study shows that Megamonas, significantly enriched in obese, degrades myo-inositol and promotes intestinal lipid absorption and obesity. Additionally, the study suggests that Megamonas has an additive effect with genetics on obesity.
