Cell ferroptosis in the pathogenesis of vitiligo and advances in related therapeutic agents
- VernacularTitle:细胞铁死亡参与白癜风发病机制与相关治疗药物研究进展
- Author:
Xuqing XU
1
;
Wen HU
;
Xiaojing KANG
Author Information
- Publication Type:Journal Article
- Keywords: Vitiligo; Ferroptosis; Reactive oxygen species; Lipid peroxidation; Oxidative stress; Drugs
- From: Chinese Journal of Dermatology 2025;58(9):886-889
- CountryChina
- Language:Chinese
- Abstract: Melanocyte death is the most notable feature of vitiligo, and ferroptosis is a unique pattern of programmed cell death, characterized by the iron-dependent accumulation of lethal lipid reactive oxygen species. Recent studies have found that ferroptosis is involved in the damage to melanocytes in the development of vitiligo. This review summarizes the possible mechanisms of ferroptosis in vitiligo and related therapeutic agents, aiming to provide novel insights into the pathogenesis of vitiligo, potential therapeutic targets, and associated targeted therapies.
