Long-term pouch function and quality of life after ileal pouch-anal anastomosis for ulcerative colitis and risk facotrs analysis
10.3760/cma.j.cn101480-20201111-00125
- VernacularTitle:溃疡性结肠炎回肠储袋肛管吻合术后远期储袋功能的影响因素分析
- Author:
Dong TAN
1
;
Tenghui ZHANG
;
Yi XU
;
Zeqian YU
;
Lei ZHAO
;
Feng ZHU
;
Dengyu FENG
;
Tengfei LYU
;
Lili GU
;
Weiming ZHU
;
Jianfeng GONG
Author Information
1. 南京大学医学院，南京 210046
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Ileal pouch-anal anastomosis;
Quality of life;
Pouch Functional Score
- From:
Chinese Journal of Inflammatory Bowel Diseases
2021;05(4):302-307
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate pouch function, quality of life, and their influencing factors after ileal pouch-anal anastomosis (IPAA) in patients with ulcerative colitis (UC) .Methods:Clinical data of 111 patients undergoing IPAA in the UC database at Department of General Surgery, Jinling Hospital from 2014 to 2020 were retrospectively analyzed. Through the questionnaire, pouch functional score (PFS) and Cleveland global quality of life (CGQL) were obtained. These patients were diveided into two groups according to the PFS score. Univariate and multivariate analysis were used to compare the clinical features and reveal the risk factors of PFS.Results:A total of 111 patients were enrolled in this study, including 65 males and 38 females. 63 patients were in the good pouch function group, and 48 in the poor pouch function group. The median score of PFS was 7 (3.0-10.0) . Univariate analysis showed that compared with the good pouch function group, the poor pouch function group had a longer duration of disease before operation[44.5 (21.0-86.0) months vs. 14.0 (5.0-70.0) months, P = 0.005], a shorter follow-up time[16.0 (7.0-28.8) months vs. 26.0 (15.0-39.0) months, P = 0.020], and a higher proportion of pouchitis (29.1% vs. 12.9%, P = 0. 031) . The multivariate logistic regression analysis showed duration of disease before operation ( OR = 0.974, 95% CI: 0.951-0.997, P = 0.030) and pouchitis ( OR = 3.251, 95% CI: 1.168-9.045, P = 0.024) were the independent risk factor of PFS in UC patients.The median CGQL was 0.77 (0.67-0.87) . The median surgical satisfaction score was 9.0 (8.0-10.0) . There was a correlation between CGQL and PFS ( rs = -0.376, P<0.001) . Conclusions:Most patients recover well after IPAA, and are highly satisfied with the operation. A good pouch function has a positive influence on the quality of life.
