Relationship between bioelectrical impedance phase angle and nutritional status in patients with Crohn′s disease
10.3760/cma.j.cn101480-20210125-00006
- VernacularTitle:克罗恩病患者生物电阻抗相位角与营养状况的关系研究
- Author:
Fu MING
1
;
Xinyao QIAO
1
;
Ya MA
1
;
Lei SHI
1
Author Information
1. 四川大学华西医院临床营养科，成都 610041
- Publication Type:Journal Article
- Keywords:
Crohn′s disease;
Phase angle;
Nutritional assessment;
Bioelectrical impedance analysis;
Nutritional risk screening 2002;
Patient-generated subjective globa
- From:
Chinese Journal of Inflammatory Bowel Diseases
2021;05(4):327-333
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between the phase angle (PhA) and nutritional status in patient with Crohn′s disease (CD) .Methods:CD patients treated in West China Hospital of Sichuan University from May 2019 to June 2020 were enrolled retrospectively. The general data and routine nutritional indexes of patients were collected. Routine nutritional indexes included physical measurement, human composition, nutritional risk screening 2002 (NRS2002) and patient-generated subjective global assessment (PG-SGA) . The PhA value of patients was measured and the diagnostic efficacy was calculated. According to Kyle standard, low PhA is defined as male PhA less than 5° and female PhA less than 4.6° under bioelectrical impedance 50 kHz. The patients were divided into normal PhA group and low PhA group. The differences in nutritional indexes between the two groups were compared, and the correlation between PhA and routine nutritional indexes was analyzed.Results:A total of 112 CD patients were enrolled in the study, including 71 males (63.4%) and 41 females (36.6%) with the age range of 15-60 years old, and 56 patients in low PhA group and 56 in normal PhA group. Taking NRS2002 score as the gold standard, the area under curve (AUC) of CD diagnosis with PhA was 0.720 (95% CI: 0.547-0.893) in men and 0.799 (95% CI: 0.647-0.950) in women. When PhA<5.5° was defined as cut-off value for men, the sensitivity was 0.80 and the specificity was 0.73. When PhA<5.1° was defined as cut-off value for women, the sensitivity was 0.81 and the specificity was 0.78. The proportion of patients with nutritional risk, PG-SGA score and edema index in low PhA group were higher than those in normal PhA group (all P<0.05) , while body mass index (BMI) , arm circumference, arm muscle circumference, waist circumference, fat mass, fat-free mass, appendicular skeletal muscle mass index, intracellular water, extracellular water, and basal metabolic rate were lower than those in normal PhA group (all P<0.05) . PhA was negatively correlated with NRS2002 score, PG-SGA score and edema index ( r = -0.26, -0.35, -0.82, all P<0.05) , while it was positively correlated with BMI, arm circumference, arm muscle circumference, waist circumference, fat-free mass, appendicular skeletal muscle mass index, intracellular water, extracellular water, and basal metabolic rate ( r = 0.38, 0.59, 0.57, 0.31, 0.36, 0.49, 0.46, 0.25, 0.39, all P<0.05) . Conclusion:There is a strong correlation between PhA value and routine nutritional indexes in CD patients, suggesting that PhA can be used as a nutritional index to evaluate the nutritional status of CD patients.
