Double-Blind Randomized Placebo-Controlled Trial of Shengjin Liyan Spray for Chemotherapy-Induced Xerostomia in Lym-phoma Patients
10.16466/j.issn1005-5509.2025.08.013
- VernacularTitle:生津利咽方喷雾治疗淋巴瘤患者化疗后口干的双盲随机对照研究
- Author:
Yufen YAO
1
;
Liqiong CHENG
;
Yiling QIU
Author Information
1. 浙江中医药大学附属第一医院 杭州 310006
- Publication Type:Journal Article
- Keywords:
Shengjin Liyan Spray;
spray;
lymphoma;
chemotherapy;
xerostomia;
randomized controlled trial;
traditional Chinese medicine;
unstimulated whole saliva
- From:
Journal of Zhejiang Chinese Medical University
2025;49(8):1044-1049
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To evaluate the efficacy of Shengjin Liyan Spray(SJLYS)in alleviating chemotherapy-induced xerostomia in lymphoma patients.[Methods]In this double-blind,randomized,placebo-controlled trial,120 lymphoma patients with chemotherapy-induced xerostomia were enrolled and equally allocated in experimental group(60 cases,receiving SJLYS)and control group(60 cases,receiving sterile water spray).The intervention was administered hourly during chemotherapy until bedtime.Primary outcomes included the numerical rating scale(NRS)for dry mouth,lip mucosal moisture score and unstimulated whole saliva(UWS)flow rate.Secondary outcome was the overall response rate.[Results]Post-treatment assessments demonstrated significantly better outcomes in experimental group,the NRS score of experimental group(2.41±1.10)was significantly lower than that of control group(4.15±1.28);the moisture score of the lip mucosa was(3.47±0.62)points,which was better than control group(2.60±0.78)points;the UWS was(0.53±0.10)mg/min,higher than that of control group(0.42±0.09)mg/min.The overall response rate in experimental group(78.33%)was markedly superior to control group(48.33%),and the above differences were statistically significant(P<0.05).[Conclusion]SJLYS significantly relieves xerostomia symptoms,enhances oral comfort,and optimizes quality of life in chemotherapy-treated lymphoma patients,demonstrating substantial clinical applicability.
