The influence of bile acid, microbiota and their interaction on inflammatory bowel disease and the related progress in clinical application
10.3760/cma.j.cn101480-20200827-00095
- VernacularTitle:肠道菌群、胆汁酸及其交互作用对炎症性肠病的影响及临床应用进展
- Author:
Mengsha CEN
1
;
Xia ZHENG
1
;
Ning DAI
1
;
Mengque XU
1
Author Information
1. 浙江大学医学院附属邵逸夫医院消化内科，杭州 310016
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Intestinal microbiota;
Bile acid;
Interaction
- From:
Chinese Journal of Inflammatory Bowel Diseases
2021;05(3):242-245
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal microbiota plays key roles in nutrient absorption, metabolism and immune defense, and is regarded as the cornerstone of maintaining the health status of human host. After entering the intestine, the bile acids synthesized in the liver can not only promote the absorption of fat-soluble substances but also directly or indirectly affect the structure and function of intestinal microbiota. Intestinal microbiota can change primary bile acids into secondary bile acids, and help it to be reabsorbed back to the liver through the enterohepatic circulation. The complex mechanism of microbiota-bile acids crosstalk is involved in the development of intestinal inflammation including inflammatory bowel disease (IBD) . This article reviews the influence of intestinal microbiota, bile acids and their interaction on the pathogenesis of IBD and the related progress of therapeutic application.
