Efficacy of evolocumab combined with bare metal stents in treatment of ostial vertebral artery stenosis
10.3969/j.issn.1009-0126.2025.09.024
- VernacularTitle:依洛尤单抗联合金属裸支架治疗椎动脉起始部狭窄的疗效分析
- Author:
Liefeng OUYANG
1
;
Hun FENG
1
;
Junjie WEI
1
;
Shuxuan HUANG
1
;
Yisong LI
1
;
Huangwei WEI
1
;
Peihu LI
1
;
Lüli LI
1
Author Information
1. 530021 南宁,广西壮族自治区人民医院(广西医学科学院)神经内科
- Publication Type:Journal Article
- Keywords:
stents;
vertebral artery;
vertebrobasilar insufficiency;
atorvastatin
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(9):1242-1245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of evolocumab combined with bare metal stents in treating stenosis at the vertebral artery ostium and its impact on restenosis.Methods A retrospective analysis was conducted on 81 patients with ostial vertebral artery stenosis undergo-ing implantation of bare mental stents in our department from January 2022 to May 2024.Based on postoperative lipid-lowering regimens,they were divided into a statin group(51 cases,atorvas-tatin alone)and a combination group(30 cases,atorvastatin combined with evolocumab).All pa-tients were followed up for 6 months postoperatively,the changes in low-density lipoprotein cho-lesterol(LDL-C)level(△LDL-C)and total cholesterol(TC)level(△TC)as well as the rate of vascular restenosis(△restenosis rate)were compared between the two groups.Results After treatment,the combination group had significantly lower LDL-C and TC levels than the statin group(P＜0.01).The △LDL-C and △TC levels were obviously higher(1.85±1.01 mmol/L vs 1.18±0.68 mmol/L,P=0.001;1.64±0.94 mmol/L vs 1.19±0.67 mmol/L,P=0.018),and the△restenosis rate was notably lower(13.3％vs 35.3％,P=0.032)in the combination group than the statin group.Conclusion Combined evolocumab and metal bare stents demonstrates good effi-cacy in treating stenosis at the origin of the vertebral artery,and can effectively lower lipid levels and helps to reduce the occurrence of vascular restenosis.
