Relationship between serum ANGPTL8 and Sema 3A levels and postoperative cerebral vasospasm in patients with intracranial aneurysm rupture
10.3969/j.issn.1009-0126.2025.09.023
- VernacularTitle:血清血管生成素样蛋白8和信号素3A水平与颅内动脉瘤破裂患者术后脑血管痉挛的关系分析
- Author:
Li NIE
1
;
Xiangliang QIAO
1
;
Wei CHENG
1
;
Suhua HU
1
;
Huanhuan HU
1
Author Information
1. 441300 湖北医药学院附属随州市中心医院神经内科
- Publication Type:Journal Article
- Keywords:
aneurysm,ruptured;
vasospasm,intracranial;
semaphorin-3A;
forecasting
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(9):1238-1241
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between serum angiopoietin-like protein 8(ANGPTL8)and semaphorin 3A(Sema 3A)levels and postoperative cerebral vasospasm(CVS)in patients with intracranial aneurysm(IA)rupture.Methods A total of 188 patients with IA rupture receiving surgical treatment in our hospital were prospectively selected during October 2021 and October 2023,and according to whether CVS occurred after surgery,they were classified into a spasm group(75 cases)and a non-spasm group(113 cases).Serum ANGPTL8 and Sema 3A levels were measured after admission.Spearman correlation analysis was performed to assess the correlation of the levels with CVS occurrence.Binary logistic regression analysis was applied to construct a prediction model with serum ANGPTL8 and Sema 3A as variables.ROC curve was plotted to evaluate the predictive value of the levels for postoperative CVS.Results The serum ANGPTL8 level was significantly higher while that of Sema 3A was obviously lower in the spasm group then the non-spasm group(P＜0.01).Binary logistic regression analysis showed that the levels of serum ANGPTL8 and Sema 3A were independent predictors of postoperative CVS in patients with ruptured IA(OR=1.021,95％CI:1.013-1.029,P=0.000;OR=0.980,95％CI:0.967-0.993,P=0.003).ROC curve analysis indicated that the AUC value,sensitivity and speci-ficity of the two indicators combined together in predicting postoperative CVS was 0.939(95％CI:0.894-0.969),89.33％and 89.38％,respectively,with better predictive efficiency than each indicator alone(P＜0.01).Conclusion Serum ANGPTL8 and Sema 3A levels are closely associat-ed with postoperative CVS in patients with IA rupture,and they can be used as effective indicators for early prediction of postoperative CVS.
