Correlation of serum BNP and D-dimer levels with cardiac function in elderly patients with chronic heart failure
10.3969/j.issn.1009-0126.2025.09.010
- VernacularTitle:老年慢性心力衰竭患者血清B型钠尿肽和D-二聚体水平及其与心功能的相关性研究
- Author:
Lianghui WANG
1
;
Di MA
1
;
Jun YIN
1
;
Yuting LI
1
;
Zhiling GAO
1
Author Information
1. 230031 合肥,安徽中医药大学第一附属医院重症医学科
- Publication Type:Journal Article
- Keywords:
heart failure;
natriuretic peptide,brain;
correlation of data
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(9):1179-1182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of serum brain natriuretic peptide(BNP)and D-dimer levels with cardiac function in elderly patients with chronic heart failure(CHF).Methods A retrospective analysis was conducted on 91 elderly CHF patients(observation group)admitted in our hospital from January 2021 to November 2024.They were then classified into grade Ⅰ-Ⅱsubgroup(66 cases)and grade Ⅲ-Ⅳ subgroup 25 cases according to NYHA cardiac function grading.Another 84 healthy individuals who underwent physical examinations in our hospital dur-ing the same period were selected as the control group.The levels of serum BNP and D-dimer were detected.Multivariate logistic regression model was used to analyze the risk factors affecting the severity of cardiac function in elderly CHF patients,and Spearman correlation analysis was adopted to analyze the correlation between the levels and cardiac function in elderly patients with CHF.Results Serum D-dimer and BNP levels were significantly higher in the observation group than the control group(P＜0.01),and in the grade Ⅲ-Ⅳ subgroup than the grade Ⅰ-Ⅱ sub-group(P＜0.01).Multivariate logistic regression analysis revealed that age(OR=2.815,95％CI:1.501-5.281,P=0.001),BNP(OR=2.901,95％CI:1.458-5.772,P=0.003)and D-dimer(OR=2.872,95％CI:1.501-5.495,P=0.002)were independent influencing factors for cardiac function in elderly CHF patients(P＜0.01).Spearman correlation analysis showed that serum BNP and D-dimer were negatively correlated with cardiac function(r=-0.324,P=0.023;r=-0.285,P=0.035).Conclusion The serum levels of D-dimer and BNP are significantly increased in elderly CHF patients,and the two levels are related to cardiac function.
