Correlation between arterial stiffness and incident chronic kidney disease among old adults taking health check-up
10.3969/j.issn.1009-0126.2025.09.009
- VernacularTitle:老年健康体检人群中动脉僵硬度与新发慢性肾脏病的相关性研究
- Author:
Guang YANG
1
;
Xin SHEN
;
Bokai CHENG
;
Jiebin HOU
;
Yabin ZHANG
;
Hongyu CHEN
;
Qingli CHENG
;
Yansong ZHENG
;
Jiahui ZHAO
Author Information
1. 100853 北京,解放军总医院第二医学中心肾脏病科
- Publication Type:Journal Article
- Keywords:
vascular stiffness;
pulse wave analysis;
kidney system diseases;
correlation of data
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(9):1173-1178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between arterial stiffness(AS)and incident chronic kidney disease(CKD)among the elderly individuals taking health checkup.Methods A retrospective study was conducted on 857 elderly individuals without CKD at baseline who taking physical exams in our medical center from December 2009 to May 2021.Their clinical and labora-tory data were collected.Brachial-ankle pulse wave velocity(baPWV)was used to assess the se-verity of AS,and then the subjects were divided into normal elasticity group(201 cases),and moderate(490 cases)and severe AS group(166 cases).Kaplan-Meier curves were plotted to dis-play cumulative incidence rates of incident CKD across different AS groups.Restricted cubic splines(RCS)and Cox regression models were applied to analyze the correlation of baPWV and incident CKD risk.Results The severe AS group had significantly advanced age,greater ratio of hypertension,larger waist circumference,higher HR,SBP and DBP,increased urinary albumin/creatinine ratio(UACR),elevated levels of TG and fasting blood glucose,and baPWV than the normal elasticity group(P＜0.05).During the follow-up period,37 participants developed CKD.The incidence of CKD was obviously higher in the severe AS group than the normal arterial elas-ticity group(9.04％vs 3.48％).RCS analysis revealed a U-shaped relationship between baPWV and incident CKD risk.When baPWV ≥1 400 cm/s,each standard deviation increase in baPWV indicates the risk of incident CKD increasing by 71％(HR=1.71,95％CI:1.30-2.25,P＜0.01).Regardless of adjustment for covariates or not,baPWV remained positive correlation with inci-dent CKD risk(P＜0.05).Conclusion Among the elderly individuals undergoing health check-up,increased AS severity is significantly associated with higher risk of incident CKD when baP-WV ≥1400 cm/s.
