The regulation role of protein ubiquitination in the development and progression of intestinal inflammation
10.3760/cma.j.cn101480-20201023-00115
- VernacularTitle:蛋白泛素化修饰在肠道炎症反应发生发展中的调控作用
- Author:
Chaohui WANG
1
;
Lingya YAO
;
Zhou ZHANG
;
Yu ZHANG
;
Qian CAO
Author Information
1. 浙江大学医学院附属邵逸夫医院消化内科，杭州 310016
- Publication Type:Journal Article
- Keywords:
Intestinal inflammation;
Ubiquitination;
Deubiquitination;
Immune response;
Innate immunity;
Specific immunity;
Cytokines
- From:
Chinese Journal of Inflammatory Bowel Diseases
2021;05(2):178-182
- CountryChina
- Language:Chinese
-
Abstract:
There are diverse pathogenic factors for intestinal inflammation, but the process of activated immune response is similar. Ubiquitination, a widespread mechanism of protein post-translational modification in cells, plays a regulatory role in signal transduction, transcriptional regulation and protein kinase activation. Ubiquitination of proteins involving in immune inflammation signaling pathways determines the balance between inflammatory mediators and anti-inflammatory factors, thus affects the progression and outcome of intestinal inflammation. This article reviews the ubiquitination modification of protein, which will help to deeply understand the pathophysiological process of intestinal inflammation, and provide a theoretical reference for the research and development of targeted new drugs in precision therapy.
