Predictive value of TyG index combined with ESM-1 for postoperative ischemia in hypertension patients with concomitant CHD
10.3969/j.issn.1009-0126.2025.09.006
- VernacularTitle:三酰甘油葡萄糖指数联合内皮细胞特异分子1对冠心病伴高血压患者术后缺血的预测价值
- Author:
Yang LI
1
;
Xiuhong HAO
Author Information
1. 476000 商丘医学高等专科学校临床医学院内科学
- Publication Type:Journal Article
- Keywords:
coronary disease;
hypertension;
forecasting;
triacylglycerol-glucose index
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(9):1158-1163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of triglyceride-glucose(TyG)index combined with endothelial cell specific molecule 1(ESM-1)for ischemic events in patients with coronary heart disease(CHD)and hypertension after percutaneous coronary intervention(PCI).Methods A retrospective analysis was performed on 208 hypertension patients with CHD undergoing PCI in the Second Cardiovascular Department of Shangqiu First People's Hospital from March 2021 to March 2024.According to the occurrence of ischemic events during 1 year after surgery,they were divided into an ischemic event group(31 cases)and a non-ischemic event group(177 cases).In 1 d after surgery,5 ml of fasting venous blood was collected to test fasting blood glucose(FBG),blood lipids,liver function,ESM-1 and other indicators,and TyG index was calculated.Multivari-ate logistic regression analysis was used to analyze the correlation of TyG index and ESM-1 with ischemic events after PCI in the patients.ROC curve was plotted to evaluate the value of TyG in-dex combined with ESM-1 in predicting ischemic events after PCI,and the AUC value was calcu-lated.Results The levels of FBG,low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),TyG index and ESM-1 were significantly higher,while the level of high-density lipoprotein cholesterol(HDL-C)was obviously lower in the ischemic event group than the non-ischemic event group(P＜0.01).Multivariate logistic regression analysis showed that hyperlipidemia,number of vessel disease,FBG,LDL-C,HDL-C,TG,TyG index and ESM-1 were independent risk factors for ischemic events in hypertension and CHD patients after PCI(P＜0.05,P＜0.01).ROC curve anal-ysis indicated that the AUC value of TyG index and ESM-1 combined together in predicting ische-mic events after PCI in hypertension patients with CHD was statistically higher than that of sin-gle indicator[0.861(95％CI:0.797-0.928)vs 0.746(95％CI:0.660-0.831)and 0.725(95％CI:0.622-0.827),P＜0.01].Conclusion High TyG index and high ESM-1 level are independent risk factors for ischemic events after PCI in hypertension patients with CHD.The combination of two indicators has good efficiency for risk of ischemic events after PCI in the patients.
