Research progress in SLCO2A1 gene related diseases

VernacularTitle:SLCO2A1基因相关性疾病的研究进展
Author: Qiang WANG ¹ ; Wenyun DING ; Yue LI ; Dong WU ; Weibo XIA
Author Information

1. 中国医学科学院　北京协和医学院　北京协和医院消化内科　100730
Publication Type:Journal Article
Keywords: Chronic enteropathy associated with SLCO2A1 gene; Primary hypertrophic osteoarthropathy; Gene, SLCO2A1; Organic anion transporting polyp
From: Chinese Journal of Inflammatory Bowel Diseases 2021;05(2):135-139
CountryChina
Language:Chinese
Abstract: Organic anion transporting polypeptide 2A1 ( SLCO2A1) gene encodes the organic anion transporting polypeptide 2A1 (OATP2A1) . OATP2A1 is widely expressed in human tissues and organs, plays an important regulatory role in prostaglandin metabolism and participates in various pathophysiological processes. The abnormality of SLCO2A1 gene can affect the prostaglandin metabolism by OATP2A1, leading to the disease. At present, the known SLCO2A1 gene related diseases include primary hypertrophic osteoarthropathy (PHO) and chronic enteropathy associated with SLCO2A1 gene (CEAS) . More attention has been paid to these diseases in recent years. Based on the functional characteristics of SLCO2A1 gene, the article introduces the pathogenesis, clinical characteristics and treatment progress of SLCO2A1 gene related diseases.