Clinical study on EGF and NF-κB regulating malignant progression of elderly gliomas
10.3969/j.issn.1009-0126.2025.09.022
- VernacularTitle:表皮生长因子和核转录因子κB调控老年脑胶质瘤患者恶性进展的研究
- Author:
Yun SHAO
1
;
Wenwen LIU
;
Jing QIN
;
Xinxin QI
Author Information
1. 430022 武汉市第一医院肿瘤科
- Publication Type:Journal Article
- Keywords:
glioma;
epidermal growth factor;
NF-kappa B;
disease progression
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(9):1233-1237
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of epidermal growth factor and nuclear transcrip-tion factor kappa B(NF-κB)in elderly gliomas and their roles in malignant progression of the dis-ease.Methods A total of 240 elderly glioma patients undergoing surgical resection in our hospital from January 2020 to January 2023 were enrolled and served as an observation group.Another 100 patients receiving surgical treatment due to traumatic brain injury in our hospital during the same period were recruited and served as the control group.Immunohistochemical assay was used to detect the expression of epidermal growth factor and NF-κB in brain tissue.Cox regression analy-sis was employed to determine the independent influencing factors of malignant progression in the elderly glioma patients.Results The observation group had significantly higher epidermal growth factor expression score and NF-κB expression score than the control group(7.44±1.16 vs 3.68±0.51,6.49±1.02 vs 3.56±0.64,P＜0.01).The age,tumor pathological grade,surgical approach,postoperative radiotherapy,and epidermal growth factor and NF-κB expression levels were inde-pendent factors affecting the progression of elderly glioma patients(P＜0.05,P＜0.01).Conclusion The epidermal growth factor and NF-κB expression levels are independent influen-cing factors of progressive disease in elderly glioma patients,and can serve as evaluation indicators for postoperative progression in the patients.
