Correlation of complex inflammation indexes and severity of acute ischemic stroke:an analysis of 278 cases
10.3969/j.issn.1009-0126.2025.09.020
- VernacularTitle:复合炎症指数与急性缺血性脑卒中严重程度的相关性分析
- Author:
Hongmei SUN
1
;
Yang LI
;
Xiukun JIN
;
Jianjun JIA
;
Jing YANG
;
Lüming ZHANG
;
Peifu WANG
Author Information
1. 100049 北京,航天中心医院神经内科
- Publication Type:Journal Article
- Keywords:
ischemic stroke;
neutrophil-to-lymphocyte ratio;
platelet-lymphocyte ratio
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(9):1225-1228
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of complex inflammation indexes,neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)with the severity of acute ische-mic stroke(AIS).Methods A total of 278 patients with brain MRI-confirmed AIS admitted in our department between March 2018 and September 2023 were enrolled retrospectively,and according to the National Institutes of Health Stroke Scale(NIHSS)score at admission,they were divided into a mild stroke group(NIHSS score≤3,n=157)and a moderate-severe stroke group(NIHSS score＞3,n=121).Clinical data and results of laboratory tests at admission were collec-ted,and NLR and PLR were calculated.Multivariate logistic regression analysis was performed to assess the association of NLR and PLR with AIS severity.Results Compared with the mild stroke group,the moderate-severe stroke group had significantly older age,larger proportions of atrial fibrillation and pre-morbid Modified Rankin Scale(mRS)score＞1,higher NLR and PLR,and higher ratio of culprit large vessel stenosis,and a lower rate of transient ischemic attack(TIA)(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that TIA(95％CI:0.017-0.455,P=0.004)was a protective factor,and pre-morbid mRS＞1(95％CI:1.451-6.700,P=0.004),NLR(95％CI:1.041-1.346,P=0.010)and culprit large vessel stenosis(95％CI:1.370-4.415,P=0.003)were risk factors for the severity of AIS.Conclusion Inflammation is involved in the pathogenesis of AIS,and the complex inflammatory index,NLR may be an inde-pendent risk factor for the severity of AIS.
