Role of dendritic cells and the RhoA signaling pathway in the pathogenesis of inflammatory bowel disease
10.3760/cma.j.cn101480-20200421-00043
- VernacularTitle:树突状细胞及其RhoA信号通路在炎症性肠病发病中的作用
- Author:
Xin GU
1
;
Lei GONG
1
;
Xiaoyun WANG
1
;
Jiahui HUO
1
Author Information
1. 南京医科大学附属无锡第二医院消化内科，无锡 214002
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Dendritic cells;
Protein, RhoA
- From:
Chinese Journal of Inflammatory Bowel Diseases
2021;05(2):183-186
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease (IBD) is a kind of heterogeneous chronic diffuse intestinal inflammation. The development and progression of IBD are closely related to immune disorders. Dendritic cell (DC) plays an important role in mucosal immunity and can exert immune tolerance in physiological conditions, but it may inhibit immune tolerance and trigger excessive inflammatory immune responses in IBD. However, the immune imbalance function of DC and its further activation of the immune signaling pathway is still unclear. As a key regulator of immune cell differentiation and function, RhoA is closely related to the morphology, proliferation, antigen uptake, cell migration and antigen presentation of DC. Abnormal RhoA signaling pathway may affect the function of DC. This article reviews the role of DC and intracellular RhoA signaling pathway in the pathogenesis of IBD, hoping to provide some enlightenments and help for the clinical treatment.
