Research on the hypocalcemia in patients with inflammatory bowel disease and its risk factors
10.3760/cma.j.cn101480-20200419-00042
- VernacularTitle:炎症性肠病患者合并低钙血症及其危险因素的研究
- Author:
Haidan SHI
1
;
Jiong JIANG
1
;
Min SONG
1
;
Chunyan WU
1
;
Hongmei LIU
1
Author Information
1. 西安交通大学第二附属医院临床营养科 710004
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Ulcerative colitis;
Crohn′s disease;
Hypocalcemia;
Risk factors
- From:
Chinese Journal of Inflammatory Bowel Diseases
2020;04(4):328-330
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the hypocalcemia in patients with inflammatory bowel disease (IBD) and its risk factors.Methods:Clinical data of 72 patients with IBD who were admitted to the Second Affiliated Hospital of Xi′an Jiaotong University from December 2017 to December 2019 were analyzed respectively, including 59 patients with ulcerative colitis (UC) and 13 with Crohn′s disease (CD) . The patients were divided into the hypocalcemia group ( n = 29) and the normal blood calcium group ( n = 43) . Univariate analysis was conducted on the influencing factors of the hypocalcemia, and the factors with statistical significance were included in the Logistic regression model for multivariate analysis. The factors were analyzed by receiver operator characteristic (ROC) curve and the area under curve (AUC) was calculated. Results:The univariate analysis showed that prealbumin, total protein, albumin, hemoglobin, total cholesterol, serum sodium, serum phosphorus, disease activity index (DAI) , Crohn′s disease activity index (CDAI) and sunshine duration ≤2 h/d were the influencing factors of hypocalcemia in IBD patients (all P<0.05) . Multivariate Logistic regression analysis showed that albumin ( OR = 3.421, 95% CI: 1.301-4.134, P = 0.008) , DAI ( OR = 3.096, 95% CI: 1.901-8.907, P = 0.024) , CDAI ( OR = 2.248, 95% CI: 1.211-7.352, P = 0.033) and sunshine duration ≤2 h/d ( OR = 1.442, 95% CI: 1.334-5.881, P = 0.007) were the independent risk factors for hypocalcemia in IBD patients. The AUC of the above four indexes were all >0.7. Conclusions:The patients with IBD are prone to hypocalcemia. If IBD patients have lower albumin, higher DAI or CDAI, and sunshine duration ≤2 h/d, the risk of hypocalcemia will increase.
