Diffusion-weighted imaging based on continuous-time random walk and fractional-order calculus models for staging of nasopharyngeal carcinoma
10.13929/j.issn.1003-3289.2025.07.010
- VernacularTitle:基于连续时间随机游走和分数阶微积分模型弥散加权成像用于鼻咽癌分期
- Author:
Li HUA
1
;
Runyu YANG
;
Qi CHENG
;
Jun LIU
Author Information
1. 安庆市立医院(安徽医科大学安庆医学中心)检验科,安徽安庆 246003
- Publication Type:Journal Article
- Keywords:
nasopharyngeal neoplasm;
neoplasm staging;
diffusion magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(7):1079-1084
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of diffusion-weighted imaging(DWI)based on continuous-time random walk(CTRW)and fractional-order calculus(FROC)models for staging of nasopharyngeal carcinoma(NPC).Methods Totally 77 patients with NPC were retrospectively enrolled and divided into high-or low-stage according to 2017 Chinese NPC staging criteria.Conventional DWI parameters(apparent diffusion coefficient[ADC])and DWI parameters based on CTRW and FROC were compared between high-or low-stage NPC,including diffusion coefficient based on CTRW(DCTRW),temporal diffusion heterogeneity index(αCTRW),spatial diffusion heterogeneity index(βCTRW),diffusion coefficient based on FROC(DFROC),fractional order derivative in space(βFROC)and spatial parameter(μFROC).The efficacy of the above parameters for staging of NPC was analyzed.Results Significant differences of DCTRW,αCTRW,DFROC,βFROC,μFROC and ADC were found between high and low clinical overall stages NPC(all P＜0.05),of DCTRW,αCTRW,DFROC and ADC between high and low T stages NPC(all P＜0.05),also of αCTRW,βFROC and μFROC between high and low N stages NPC(all P＜0.05).DCTRW,DFROC and μFROC were impact factors of clinical overall stage of NPC(all P＜0.05),with the area under the curve(AUC)of their combination of 0.890.DCTRW,αCTRw and DFROC were impact factors of T stage of NPC(all P＜0.05),and the AUC of their combination was 0.799.μFROC was the impact factor of N stage of NPC(P＜0.05),and its AUC was 0.722.Conclusion DWI parameters based on CTRW and FROC models could be used for staging of NPC,which had better values than ADC.
