Association of abnormal expression of angiotensin-converting enzyme and lipoprotein(a) with hypertension-diabetes comorbidity
10.3969/j.issn.1009-0126.2025.09.004
- VernacularTitle:血管紧张素转换酶和脂蛋白(a)异常表达与高血压和糖尿病共病的关系
- Author:
Lingming ZHANG
1
;
Xiaoluan LI
1
;
Yonggui LI
1
;
Xiaoli LIU
1
;
Xianjin CHONG
1
;
Lixin YANG
1
Author Information
1. 810000 西宁,青海省人民医院内分泌科
- Publication Type:Journal Article
- Keywords:
lipoprotein(a);
hypertension;
diabetes mellitus;
multiple chronic conditions
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(9):1148-1152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between abnormal expression of angiotensin-converting enzyme(ACE)and lipoprotein(a)[Lp(a)]with hypertension-diabetes comorbidity.Methods A case-control analysis was conducted on 342 patients with metabolic diseases admitted in our hospital between January 2021 and May 2024,and they were divided into in a diabetes-hypertension comorbidity group(114 cases),a diabetes group(114 cases)and a hypertension group(114 cases).Another 114 matched healthy individuals who taking physical examination in our hospital during the same period were subjected and served as the control group.Clinical data were collected and serum levels of ACE and Lp(a)were measured in all the groups.Multivariate logistic regression analysis was applied to analyze the independent risk factors for hypertension-diabetes comorbidity,and ROC curve analysis was performed to evaluate and predict the efficacy.Results The serum levels of ACE and Lp(a)were significantly higher in the comorbidity group than the control,hypertension and diabetes groups(P＜0.01),and in the hypertension and diabe-tes groups than the control group(P＜0.01).After adjusting for waist-to-hip ratio,alanine amin-otransferase and triglyceride,multivariate logistic regression analysis revealed that serum ACE and Lp(a)still were risk factors for the occurrence of hypertension-diabetes comorbidity(P＜0.01).ROC curve analysis demonstrated that when the cut-off value was 39.01 pg/L,ACE had an AUC value of 0.884(95％CI:0.789-0.980),a sensitivity of 76.67％and a specificity of 75.28％in predicting the comorbidity,and when the cut-off value for Lp(a)was 254.33 mg/L,the AUC value was 0.899(95％CI:0.799-0.919),the sensitivity was 85.83％,and the specificity was 82.22％.Their combination improved the AUC value to 0.993(95％CI:0.979-1.000),with a sensitivity of 95.00％and a specificity of 95.28％in the prediction.Conclusion Serum ACE and Lp(a)are independent risk factors for hypertension-diabetes comorbidity,and can be combined together and regarded as biomarkers for early identification of the comorbidity.
