Association of neutrophil-to-lymphocyte ratio with mortality risk in elderly hypertensive patients
10.3969/j.issn.1009-0126.2025.09.003
- VernacularTitle:中性粒细胞与淋巴细胞比值与老年高血压患者死亡风险的关联
- Author:
Shan LI
1
;
Li AN
;
Zhiqing FU
;
Wei ZHANG
;
Quanjin SI
Author Information
1. 100143 北京,解放军总医院第二医学中心保健三科
- Publication Type:Journal Article
- Keywords:
inflammation;
hypertension;
death;
neutrophil-to-lymphocyte ratio
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(9):1142-1147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of neutrophil-to-lymphocyte ratio(NLR)with all-cause and cause-specific mortality in elderly hypertensive patients.Methods In this cohort study,9939 elderly hypertensive patients were enrolled from the National Health and Nutrition Examination Survey between 1999 and 2018.According to the quartile of NLR,the participants were divided into Q1(n=2461),Q2(n=2460),Q3(n=2522)and Q4(n=2496)groups.Their survival status was determined based on National Death Index records.Cox proportional risk regression model,restricted cubic spline curve,Kaplan-Meier survival analysis and ROC analysis were performed.Results After adjusting for confounding factors,Cox proportional risk regression analysis showed a progressive increase in all-cause and cause-specific mortality across quartiles of NLR in elderly hypertensive patients.Compared with the Q1 group,the Q4 group had higher risks for all-cause mortality(HR=1.52,95％CI:1.32-1.74,P=0.000),cardiovascular mortality(HR=2.04,95％CI:1.63-2.56,P=0.000),and non-cardiovascular mortality(HR=1.30,95％CI:1.11-1.53,P=0.000)after adjustment.Restricted cubic spline curve analysis indicated that NLR was positively correlated with all-cause mortality,cardiovacular mortality and non-cardio-vascular mortality.More pronounced association between NLR and cardiovascular death was observed in patients not taking statins(P=0.035).ROC analysis revealed that the AUC value of NLR in predicting all-cause mortality,cardiovascular mortality and non-cardiovascular mortality was 0.612,0.597 and 0.581,respectively,showing better performance than high-sensitivity C-reac-tive protein and neutrophils.Conclusion Elevated NLR level is independently associated with increased risks of all-cause and cause-specific mortality in elderly hypertensive patients.In the patients not taking statins,a stronger association is observed between NLR and cardiovascular mortality.
