The diagnostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in the active period of pediatric Crohn′s disease
10.3760/cma.j.cn101480-20200527-00058
- VernacularTitle:中性粒细胞/淋巴细胞联合血小板/淋巴细胞对儿童克罗恩病活动期的诊断价值
- Author:
Aimin QIAN
1
;
Fengfei JIAO
;
Zhihua ZHANG
;
Kunlong YAN
;
Zhifeng LIU
Author Information
1. 南京医科大学附属儿童医院新生儿医疗中心，南京 210008
- Publication Type:Journal Article
- Keywords:
Crohn′s disease;
Child;
Neutrophil-to-lymphocyte ratio;
Platelet-to-lymphocyte ratio
- From:
Chinese Journal of Inflammatory Bowel Diseases
2021;05(1):73-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the correlation of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with the activity of pediatric Crohn′s disease (CD) , and to study the efficacy of NLR and PLR independently and combinedly in predicting active period of pediatric CD.Methods:A total of 43 children with CD (145 clinical records) admitted to Gastroenterology Department of Children′s Hospital of Nanjing Medical University from June 2017 to March 2020 were analyzed retrospectively. According to pediatric Crohn′s disease activity index, the clinical records were divided into inactive group (94 cases) , mild active group (29 cases) , moderate to severe active group (22 cases) . General information of the children and NLR and PLR results of each group on the second day after admission were collected.Results:The levels of NLR and PLR in mild active group and moderate to severe group were higher than those in inactive group [NLR: 2.96 (2.25, 4.12) vs. 1.10 (0.77, 1.92) , 3.25 (2.50, 5.53) vs. 1.10 (0.77, 1.92) ; PLR: 194.97 (143.30, 238.64) vs. 101.83 (81.75, 147.40) , 198.85 (166.95, 244.95) vs. 101.83 (81.75, 147.40) , P<0.001], but there was no significant difference between mild active group and moderate to severe active group. There were a strong positive correlation between NLR and PLR with CD activity ( rs = 0.622, P<0.001; rs = 0.582, P<0.001, respectively) . The cut-off values of NLR and PLR for predicting CD activity were 1.64 and 136.88, and the AUC was 0.877 and 0.855, respectively. The corresponding sensitivity and specificity were 96.08%, 71.28% and 84.31%, 74.47%, respectively. When NLR was combined with PLR, AUC was 0.891, sensitivity was 86.27%, and specificity was 78.72%. Conclusions:NLR and PLR can be used to distinguish the active and inactive periods of pediatric CD. The combination of NLR and PLR can be used to diagnose the active period of pediatric CD with higher AUC, sensitivity and specificity.
