Research progresses of bicyclic peptide-based radionuclide probes in diagnosis and treatment of tumors
10.13929/j.issn.1003-3289.2025.08.038
- VernacularTitle:双环肽类核素探针用于诊疗肿瘤研究进展
- Author:
Xing YANG
1
;
Mengjie DONG
;
Yanhua DUAN
;
Baixuan XU
;
Gang HUANG
Author Information
1. 北京大学人民医院核医学科,北京 100044
- Publication Type:Journal Article
- Keywords:
neoplasms;
radioactive tracers;
radionuclide imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(8):1404-1411
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear medicine plays a pivotal role in diagnosis and treatment of tumors.The development of radionuclide probes with high affinity and specificity is an effective approach to achieve precise diagnosis and treatment of tumors.With high binding affinity,rapid tissue penetration and excellent pharmacokinetic properties,bicyclic peptide-based radionuclide probes demonstrate remarkable advantages in diagnosis and targeted therapy of tumors.The structural characteristics and design strategies of bicyclic peptide-based radionuclide probes were reviewed in this article,mainly focused on research progresses in targeting tumor-associated receptors.
