Role of interleukin 9 in inflammatory bowel disease
- VernacularTitle:白介素9在炎症性肠病中的作用
- Author:
Fang ZHANG
1
;
Yuemei DONG
1
;
Meihua ZHAO
1
;
Na MA
1
;
Muhan ZHANG
1
;
Binbin WANG
1
;
Baisui FENG
1
Author Information
- Publication Type:Journal Article
- Keywords: Inflammatory bowel disease; Interleukin 9; Tight junction
- From: Chinese Journal of Inflammatory Bowel Diseases 2020;04(3):262-265
- CountryChina
- Language:Chinese
- Abstract: Interleukin 9 (IL-9) is secreted by polar Th2 cells and its expression is regulated by a variety of signaling factors, which is closely related to cytokine microenvironment, autoimmune diseases and allergic diseases. Inflammatory bowel disease (IBD) is a kind of intestinal nonspecific chronic inflammatory intestinal disease with uncertain etiology. It has been found that the immune imbalance of intestinal mucosa is closely related to its pathogenesis. IL-9 is involved in the pathophysiological process of IBD by regulating the expressions of tight junction associated proteins and affecting the barrier function of intestinal mucosa. This review presents the role of IL-9 in IBD.
