Advancing fibroblast-targeted radionuclide imaging toward clinical translation in cardiovascular fibrosis
10.13929/j.issn.1003-3289.2025.08.035
- VernacularTitle:推进成纤维细胞核素显像在心血管纤维化中的应用
- Author:
Minfu YANG
1
;
Li HUO
;
Yaming LI
Author Information
1. 首都医科大学附属北京朝阳医院核医学科,北京 100020
- Publication Type:Journal Article
- Keywords:
cardiovascular system;
fibroblasts;
enzyme activation;
radionuclide imaging;
molecular imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(8):1378-1383
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial fibrosis(MF)represents a core pathological basis for cardiovascular disease progression,strongly associated with poor prognosis.The clinical evaluation techniques were invasive,lacking specificity and unable to diagnose early MF.Targeted on activated fibroblasts,radionuclide imaging emerged as a transformative solution,leveraging molecular-level specificity for noninvasive early diagnosis,dynamicly monitoring disease progression and evaluation on treatment response of MF.The scientific foundation,evidences of early diagnostic efficacy,and potential of fibroblast-targeted radionuclide imaging applicated in cardiovascular diseases,as well as its role in risk stratification,prognostic assessment and therapeutic decision support of MF were systematically reviewed in this article.
