Analysis of clinical characteristics and risk factors of Clostridium difficile infection in ulcerative colitis
10.3760/cma.j.cn101480-20191107-00130
- VernacularTitle:溃疡性结肠炎患者合并艰难梭菌感染的临床特征及危险因素分析
- Author:
Ruimiao ZHANG
1
;
Fengrong YIN
;
Fei HAN
;
Dong WANG
;
Xiaoxia HUO
;
Jia SONG
;
Hong ZHANG
;
Jinbo GUO
;
Jianhong ZHAO
;
Xiaolan ZHANG
Author Information
1. 河北医科大学第二医院消化内科 河北省消化病重点实验室 河北省消化病研究所，石家庄 050000
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Clostridium difficile;
Clinical characteristics;
Risk factors
- From:
Chinese Journal of Inflammatory Bowel Diseases
2020;04(3):212-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors and clinical features of Clostridium difficile infection (CDI) in ulcerative colitis (UC) patients. Methods:Clinical data of UC patients in hospital with complete CDI screening information at Department of Gastroenterology, The Second Hospital of Hebei Medical University from January 2015 to January 2018 were analyzed retrospectively. These patients were divided into two groups according to whether they were diagnosed with CDI. Demographic characteristics and clinical features of CDI in UC patients were analyzed. Univariate and multivariate analysis were used to reveal the risk factors of CDI.Result:A total of 162 UC patients were enrolled in this study, including 84 males and 78 females. Thirty-seven UC patients (22.8%) were diagnosed with CDI. Compared with the non-CDI group, the CDI group had a higher proportion of patients who used glucocorticoids (62.2% vs. 25.6%, P<0.05) and infliximab (13.5% vs. 1.6%, P<0.05) . The multivariate logistic regression analysis showed glucocorticoids treatment was the independent risk factor of CDI in UC patients ( OR = 4.111, 95% CI: 1.581-9.131, P = 0.001) . Conclusion:Systemic treatment with glucocorticoids increases the risk of CDI in UC patients.
