The dual role and research status of autophagy in colorectal cancer
10.3781/j.issn.1000-7431.2024.2308-0444
- VernacularTitle:自噬在结直肠癌中的双重作用和研究现状
- Author:
Chengxiang YANG
1
;
Yan LI
Author Information
1. 重庆大学附属肿瘤医院肿瘤内科,重庆 400000;重庆大学医学院,重庆 400000
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Autophagy;
Tumorigenesis;
Recurrence and metastasis;
Immune microenvironment
- From:
Tumor
2024;44(3):252-261
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer(CRC)is one of the most common malignant tumors of the digestive system whose incidence is increasing year by year.Autophagy is a process of intracellular self-degradation under stress conditions and plays dual roles by inhibiting or promoting the occurrence,development,recurrence,metastasis,and treatment sensitivity of CRC under different conditions.This review summarizes the roles of autophagy in the occurrence,development,recurrence,and metastasis of CRC,as well as its influence on the immune microenvironment and therapeutic efficacy,proposed potential autophagy-related therapeutic targets,in the hope to provide new ideas for the treatment of CRC.
