Analysis of serum antibodies in 199 cases of pediatric inflammatory bowel disease
10.3760/cma.j.cn101480-20191216-00149
- VernacularTitle:199例炎症性肠病患儿血清抗体检测结果分析
- Author:
Yaoyao ZHONG
1
;
Dexiu GUAN
1
;
Feihong YU
1
;
Jin ZHOU
1
;
Guoli WANG
1
;
Xiwei XU
1
Author Information
1. 首都医科大学附属北京儿童医院消化科 首都医科大学消化病学系 国家消化系统临床医学研究中心，北京 100045
- Publication Type:Journal Article
- Keywords:
Child;
Crohn′s disease;
Ulcerative colitis;
Antibodies, Perinuclear anti-neutrophil cytoplasmic;
Antibodies, Anti-saccharomyses cerevisiae;
Antibodies, Exo
- From:
Chinese Journal of Inflammatory Bowel Diseases
2020;04(3):240-243
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the positive rate and the value of differential diagnosis of four serum antibodies, including perinuclear anti-neutrophil cytoplasmic antibody (pANCA) , anti-saccharomyses cerevisiae antibody (ASCA) , antibodies against exocrine pancreas (PAB) and antibodies to intestinal goblet cells (GAB) in pediatric inflammatory bowel disease (IBD) .Methods:A retrospective analysis was performed on 199 IBD patients in Beijing Children′s Hospital of Capital University from January 2013 to June 2019, including 109 cases of Crohn′s disease (CD) and 90 cases of ulcerative colitis (UC) . The data of pANCA, ASCA, GAB, PAB were collected. Taking the clinical diagnosis as standard, the sensitivity, specificity, positive predictive value and negative predictive value of the four antibodies alone and combination for the diagnosis of UC and CD were calculated.Results:The positive rate of pANCA in UC group was obviously higher than that in CD group (32.22% vs. 18.35%, P<0.05) , while the positive rate of ASCA was significantly higher in CD group than that in UC group (27.52% vs. 10.00%, P<0.05) . There were no significant differences in the positive rates of PAB and GAB between CD group and UC group. In CD patients, the diagnostic sensitivity of ASCA was 27.52%, and the specificity was 90.00%; the diagnostic sensitivity of ASCA +/GAB -, pANCA -/ASCA + and ASCA +/PAB - to CD was 26.61%, 22.94%, 22.02%, and the specificity was 90.00%, 95.55% and 92.22%, respectively. In children with UC, the diagnostic sensitivity of pANCA was 32.22%, and the specificity was 81.65%; the diagnostic sensitivity of pANCA +/GAB -, pANCA +/ASCA -, pANCA +/PAB - to UC was 31.11%, 28.89%, 25.56%, and the specificity was 81.65%, 86.23%, and 83.49%, respectively. Other antibodies alone or combinations were not effective in the differential diagnosis of CD and UC (all P<0.05) . Conclusions:Positive rate of pANCA is higher in UC children and positive rate of ASCA is higher in CD children. Each antibody alone or combination has low sensitivity and high specificity in the differential diagnosis of CD and UC.
