Clinical effects of Tongdu Huoxue Decoction on patients with cervical spondylosis of vertebral artery type
10.3969/j.issn.1001-1528.2024.10.015
- VernacularTitle:通督活血汤对椎动脉型颈椎病患者的临床疗效
- Author:
Yu-mo XIONG
1
;
Zi-chen LI
;
Ying LI
;
Qiang-bing XIAO
;
Li-hua WANG
;
Hao HU
;
Rui-bing FENG
;
Jie QIAO
;
Yan HU
Author Information
1. 湖北省中医院(湖北中医药大学附属医院、湖北省中医药研究院)骨伤诊疗中心,湖北武汉430074
- Publication Type:Journal Article
- Keywords:
Tongdu Huoxue Decoction;
Betahistine Hydrochloride Tablets;
cervical spondylosis of vertebral artery type
- From:
Chinese Traditional Patent Medicine
2024;46(10):3283-3288
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the clinical effects of Tongdu Huoxue Decoction on patients with cervical spondylosis of vertebral artery type.METHODS Eighty-five patients were randomly assigned into control group (44 cases) for 14-day administration of Betahistine Hydrochloride Tablets,and observation group (41 cases) for 14-day administration of both Tongdu Huoxue Decoction and Tongdu Huoxue Decoction.The changes in clinical effects,hemorheological indices ( vertebral artery resistance index,vertebral artery systolic blood flow velocity,vertebral artery diastolic blood flow velocity),TCM syndrome scores,disease-related serum indices ( NSE,NPY,NF-κB),cervical motion indices ( flexion and extension range of motion,cervical curvature,horizontal vertebral displacement),hemodynamic indices ( whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity) and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group ( P<0.05 ).After the treatment,the two groups displayed decreased vertebral artery resistance index,disease-related serum indices,TCM syndrome scores,horizontal vertebral displacement,hemodynamic indices ( P<0.05 ),and increased vertebral artery systolic blood flow velocity,vertebral artery diastolic blood flow velocity,flexion and extension range of motion,cervical curvature ( P<0.05 ),especially for the observation group ( P<0.05 ).No significant difference in incidence of adverse reactions was found between the two groups (P>0.05).CONCLUSION For the patients with cervical spondylosis of vertebral artery type,Tongdu Huoxue Decoction can safely and effectively improve TCM syndrome scores and cervical motion,whose mechanisms may contribute to the regulation of hemorheology,hemodynamics and disease-related serum indices.
