Development and application of diphtheria-tetanus-pertussis containing combined vaccines
10.3760/cma.j.cn112338-20241224-00822
- VernacularTitle:含白喉-破伤风-百日咳成分的联合疫苗研发和应用
- Author:
Sha ZHANG
1
;
Li LI
;
Ruyue HU
;
Lei CAO
;
Xin LIU
;
Jiakai YE
;
Yifan SONG
;
Zhaonan ZHANG
;
Wenzhou YU
Author Information
1. 传染病溯源预警与智能决策全国重点实验室，中国疾病预防控制中心，北京 100050
- Publication Type:Journal Article
- Keywords:
Diphtheria-tetanus-pertussis;
Combined vaccine;
Vaccine development and application;
Challenges and recommendations
- From:
Chinese Journal of Epidemiology
2025;46(9):1667-1672
- CountryChina
- Language:Chinese
-
Abstract:
Combined vaccines can simplify the vaccination process, improve coverage rates, reduce the risk of adverse events following immunization, lower social costs, and improve the timeliness of childhood vaccination. This article focuses on multi-component vaccines based on the diphtheria-tetanus-pertussis containing vaccine. Globally, multiple combined vaccines have been developed and marketed, but the development of combined vaccine is still in its infancy stage in China, with limited vaccine types and doses available. The research, development, and application of combined vaccines still face numerous challenges in China, including technical challenges in research and development, as well as insufficient motivation for research and development. Additionally, the high cost of existing combined vaccines, coupled with low public awareness and weak vaccination intentions, significantly hinders their widespread application, China should continue to rigorously implement the Vaccine Administration Law of the People's Republic of China, promote innovative development of combined vaccines, increase public awareness, strengthen child guardians' confidence in vaccination, and improve the accessibility and affordability of combined vaccines to protect public health across all life stages.
