Pathogen genome databases development and application in public health
10.3760/cma.j.cn112338-20241227-00830
- VernacularTitle:病原体基因组数据库在公共卫生中的发展及应用
- Author:
Ziquan LYU
1
;
Yanbo YANG
;
Yu ZHANG
;
Xiangjie YAO
;
Xuemei LU
;
Yulin FU
;
Xiran WANG
;
Qinghua HU
;
Xuan ZOU
Author Information
1. 深圳市疾病预防控制中心，深圳 518055
- Publication Type:Journal Article
- Keywords:
Epidemiology;
Pathogens;
Genome;
Public health;
Databases
- From:
Chinese Journal of Epidemiology
2025;46(9):1697-1703
- CountryChina
- Language:Chinese
-
Abstract:
Infectious diseases continue to pose a threat to global public health. Successive global shocks caused by emerging and re-emerging pathogens have continuously challenged existing surveillance systems, highlighting the urgent need to build efficient and precise pathogen surveillance networks. Pathogen genomic databases have been developed rapidly in recent two decades, significantly improving the molecular identification, evolutionary analysis, and transmission tracking of pathogens, and changing disease surveillance strategies and patterns. This paper summarizes the developmental history and current state of pathogen genomic databases, and discusses their applications in public health, including pathogen variation surveillance, emerging or suspected pathogen identification, and epidemiological tracing. Furthermore, this paper systematically analyzes the limitations and key challenges faced by current global health prevention and control system, and suggests the focus of the development of online pathogen databases to address existing shortcomings, ultimately improve global infectious disease surveillance and early warning
