Clinical effects of Astragali Radix on patients with type 2 diabetes mellitus of Qi Deficiency Pattern
10.3969/j.issn.1001-1528.2024.10.014
- VernacularTitle:黄芪对气虚证2型糖尿病患者的临床疗效
- Author:
Yun-yi YANG
1
;
Hong-jie YANG
;
Li-juan ZHANG
;
Lin CHEN
;
Ke-ke HOU
;
Hong-ping YIN
;
Tao LEI
;
Wen-jun SHA
Author Information
1. 上海中医药大学,上海201203;上海中医药大学附属普陀医院,上海200062
- Publication Type:Journal Article
- Keywords:
Astragali Radix;
type 2 diabetes mellitus;
Qi Deficiency
- From:
Chinese Traditional Patent Medicine
2024;46(10):3278-3283
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Astragali Radix on patients with type 2 diabetes mellitus of Qi Deficiency Pattern.METHODS Ninety patients were randomly assigned into control group (45 cases) for 12-week intervention of both conventional treatment and original treatment regimen,and observation group (45 cases) for 12-week intervention of conventional treatment,original treatment regimen and Astragali Radix granules.The changes in TCM syndrome effects and scores,vascular endothelial function indices and inflammatory cytokines (FMD,NO,ET-1,MHR,CRP),glucose metabolism indices (FBG,2 hPBG,HbA1C,FCP),lipid metabolism indices (TC,TG,HDL-C,LDL-C) and safety indices were detected.RESULTS The observation group demonstrated higher total effective rate of TCM syndromes than the control group ( P<0.05).After the treatment,the observation group displayed higher FMD and NO than the control group (P<0.05),along with lower MHR,2 hPBG,HbA1C,TC,TG and scores for shortness of breath,fatigue,weakness ( P<0.05).No obvious adverse reactions were observable in the two groups.CONCLUSION For the patients with type 2 diabetes mellitus of Qi Deficiency Pattern,Astragali Radix can safely and effectively improve vascular endothelial dysfunction,which is worthy of clinical popularization.
