Quassinoids and lignans from Brucea javanica and their anti-inflammatory activities

VernacularTitle:鸦胆子苦木内酯类与木脂素类成分及其抗炎活性研究
Author: Tong-tong LUAN ¹ ; Ya-ling HE ; Lu XIN ; Kang-ting MENG ; Yong-hong LIU ; Zhi-wei SU
Author Information

1. 广西中医药大学海洋药物研究院/广西海洋药物重点实验室,广西南宁 530200
Publication Type:Journal Article
Keywords: Brucea javanica (L.) Merr.; quassinoids; lignans; isolation and identification; anti-inflammatory activities
From: Chinese Traditional Patent Medicine 2024;46(12):4035-4041
CountryChina
Language:Chinese
Abstract: AIM To study the quassinoids and lignans from Brucea javanica (L.) Merr.and their anti-inflammatory activities.METHODS The extract was isolated and purified by silica gel,MCI,Sephadex LH-20 and HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Seven quassinoids were isolated and identified as bruceanic acid E (1),15-O-(3-hydroxy-3-methy1butanoyl)-brucealide (2),bruceine L (3),aglycone of yadanzioside D (4),javanicolide A (5),javanicolide C (6),bruceanic acid A (7).Four lignans were isolated and identified as cleomiscosin A (8),ceplignan (9),threo-guaiacylglycerol 8'-(4-hydroxymethyl-2-methoxyphenyl) ether (10),erythro-guaiacylglycerol 8'-(4-hydroxy-methyl-2-methoxyphenyl) ether (11).Compounds 3,8 could inhibit NO release in RAW264.7 cells.CONCLUSION Compounds 9-11 are isolated from Brucea genus for the first time.Compounds 3 and 8 have anti-inflammatory activities.