Exploration on Medication Law of Professor Zeng Binfang in the Treatment of Hepatitis B Virus-Related Cirrhosis in Compensatory Stage Based on Data Mining
10.19879/j.cnki.1005-5304.202405106
- VernacularTitle:基于数据挖掘探究曾斌芳治疗代偿期乙型肝炎肝硬化用药规律
- Author:
Wanqing SUN
1
;
Feng GUO
;
Xiaozhong WANG
;
Binfang ZENG
Author Information
1. 新疆医科大学中医学院,新疆乌鲁木齐 830017;昌吉回族自治州中医医院,新疆昌吉 831100
- Publication Type:Journal Article
- Keywords:
hepatitis B virus-related cirrhosis in compensatory stage;
data mining;
Chinese materia medica;
experience of famous doctors;
Zeng Binfang
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(1):49-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the medication law of Professor Zeng Binfang for the treatment of hepatitis B virus-related cirrhosis in compensatory stage through data mining technology.Methods Medical case data of patients with hepatitis B virus-related cirrhosis in compensatory stage treated by Professor Zeng Binfang in outpatient clinics and hospital wards from October 2018 to November 2023 were collected.Patients'basic information and diagnoses were systematically input into Excel 2021 to create a standardized medical case database.Ancient and Modern Medical Case Cloud Platform 2.3.9 was used to perform statistical analysis on drug frequency,properties,tastes and meridians,efficacy classification,and association rules,hierarchical clustering,and complex networks were conducted.Results Totally 555 prescriptions were included,involving 303 kinds of Chinese materia medica,and a total frequency of 8 276 times.38 kinds of high-frequency Chinese materia medica were identified.The main properties were neutral,warm and cold,the main tastes were sweet,bitter and pungent,the main meridians were spleen meridians,liver meridians,and the main efficacy was tonics,urine excretion to strain off dampness,heat-clearing drugs,and promoting blood circulation and reducing blood stasis drugs.Association rules and hierarchical clustering resulted in 15 drug pairs and 5 clustered formulas,respectively.The core TCM combinations constructed by complex network was Angelicae Sinensis Radix,vinegar Trionycis Carapax,Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,Bupleuri Radix,Poria,Polyporus,Chuanxiaong Rhizoma,Scutellariae Radix,and Atractylodis Macrocephalae Rhizoma.Conclusion Professor Zeng Binfang advocates for a treatment protocol that"liver spleen coordination"and"Yi Gui homology",and applies the combination of"elimination"and"cleaning"methods to the"supplement"method during the stage of excessive pathogenic factors energy and deficiency of healthy qi in patients with hepatitis B virus-related cirrhosis in compensatory stage according to underlying pathogenic characteristics of damp-heat toxin retention with the blood syndrome and chronic deficiency with stasis.This combination of attacking and supplementing,as well as regulating cold and heat,can provide a certain reference for clinical treatment.
