Chemical constituents from the leaves of Ziziphus jujuba var.spinosa and their anti-inflammatory activities
10.3969/j.issn.1001-1528.2024.12.020
- VernacularTitle:酸枣叶化学成分及其抗炎活性研究
- Author:
Jin-yan TAN
1
;
Tao LI
1
;
Ze-jia NIU
1
;
He DU
1
;
Xiang-ping PEI
1
;
Chen-hui DU
1
Author Information
1. 山西中医药大学中药与食品工程学院,山西 晋中030619
- Publication Type:Journal Article
- Keywords:
Ziziphus jujuba Mill.var.spinosa (Bunge) Hu ex H.F.Chou;
leaves;
sesquiterpenes;
triterpenoids;
isolation and identification;
anti-inflammatory activities
- From:
Chinese Traditional Patent Medicine
2024;46(12):4029-4035
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from the leaves of Ziziphus jujuba Mill.var.spinosa (Bunge) Hu ex H.F.Chou and their in vitro anti-inflammatory activities.METHODS The 70％ ethanol extract from the leaves of Z.jujuba var.spinosa was isolated and purified by various modern chromatographic methods,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Their in vitro anti-inflammatory activities were evaluated by RAW264.7 model.RESULTS Fourteen compounds were isolated and identified as ampelopsisionoside (1),(3S,6S)-cis-linalool-3,7-oxide-β-D-glucopyranoside (2),alangionoside L (3),2-{(2S,5R)-5-[(1E)-4-hydroxy-4-methylhexa-1,5-dien-1-yl]-5-methyltetra-hydrofuran-2-yl} propan-2-yl β-D-glucopyranoside (4),(-)-nectandrin B-β-D-glucopyranoside (5),nikoenoside (6),kiwiionoside (7),dendranthemoside A (8),tormentic acid (9),2α,3β,19α-trihydroxy-urs-12-en-28 oic acid (10),2α-hydroxybetulinic acid (11),2α-hydroxylursolic acid (12),ceanothanolic acid (13),and maslinic acid (14).Compounds 10,11,13 and 14 could inhibit the production of NO in RAW264.7 cells.CONCLUSION Compounds 1,2,4 are first isolated from Rhamnaceae family,and 3,5,6,8 are first isolated from this plant.Compounds 10,11,13 and 14 have significant anti-inflammatory activities.
